• Sharebar

dr crapo q and a

resveratrol_molecule_extractGenesis™ Standardized Ingredients

5. X’tranol-24™

  • Resveratrol
  • Whole red wine extracts
  • Standardized to 95% polyphenols
  • High S-ORAC melon extract
  • With primary antioxidants
  •  SOD
  • Glutathione


whole red wine extract resveratrolResveratrol (trans-3,5,4′-trihydroxystilbene), is a compound found largely in the skins of red grapes. It came to scientific attention only recently, however, as a possible explanation for the “French Paradox” – the low incidence of heart disease among the French people, who eat a relatively high-fat diet. Today, it is being examined by scientific researchers as an antioxidant, an anti-cancer agent, anti-mutagen and anti-inflammatory which helps protect against cardiovascular disease.

Resveratrol is a powerful polyphenol that has been shown to activate the longevity gene. The mechanisms of resveratrol’s apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. A new report indicates that resveratrol activates Sirtuin 1 (SIRT1) and PGC-1α and improve functioning of the mitochondria within the cells.

Resveratrol is also a phytoalexin.

Phytoalexins are antibiotics produced by plants that are under attack. Phytoalexins tend to fall into several classes; however, researchers often find it convenient to extend the definition to include all phytochemicals that are part of the plant’s defensive arsenal.


While present in other plants, such as eucalyptus, spruce, and lily, and in other foods such as mulberries and peanuts, resveratrol’s most abundant natural sources are Vitis vinifera, which are used to make wine. It occurs in the vines, roots, seeds, and stalks, but its highest concentration is in the skin, which contains 50-100 micrograms (μg) per gram. Resveratrol is a phytoalexin, a class of antibiotic compounds produced as a part of a plant’s defense system against disease. For example, in response to an invading fungus, resveratrol is synthesized from p-coumaroyl CoA and malonyl CoA. Since fungal infections are more common in cooler climates, grapes grown in cooler climates have a higher concentration.


The resveratrol content of wine is related to the length of time the grape skins are present during the fermentation process. Thus the concentration is significantly higher in red wine than in white wine, because the skins are removed earlier during white-wine production, lessening the amount that is extracted. Grape juice, which is not a fermented beverage, is not a significant source of resveratrol. A fluid ounce of red wine averages 160 μg of resveratrol, compared to peanuts, which average 73 μg per ounce.

Whole Red Wine Extracts (No alcohol)

genesis has resveratrolOf course red wine comes from grapes, which can be referenced above. Red wine contains polyphenols which are mentioned directly above in regards to Resveratrol, which is one of many types of these powerful and beneficial phytonutrients.

Plant polyphenols have a very diverse pharmacological spectrum of activity. A polyphenolic antioxidant is a type of antioxidant containing a polyphenolic substructure. In human health these compounds, numbering over 4,000 distinct species, are thought to be instrumental in com- bating oxidative stress, a process associated with some neurodegenerative diseases, premature or accelerated aging and some cardiovascular diseases.

Whole wine extracts include:

  • Resveratrol Oligomers

  • Proanthocyanidole

  • B1, B2, B3, B4

  • Flavanols

  • Monomers

  • Catechin

  • Epicatechin

  • Epicatechin gallate